I'll put in a vote for grabbing some salsa and getting a Taco.
Clint's got a good point, as does radiant.
I tend to scratch out the basics on paper, then refine it on graph paper, and then take it to photoshop to draw up a preview. Then when I need a preview for the design concept, I spit it out in a low res jpg.
Once finalized, I create any necessary graphics in PS.
Then I keep the preview image up, and go back to taking notes (OK, chicken scratch) on paper. I'll make general notes in pseudo code about overall div structure, etc.
Then it's on to Taco and spitting out the main div structure, while adding in some basic stuff in a separate open stylesheet.
Then I build on it and go from there.
Once I have the basic layout, I'll look at it in Safari and FF. Usually at this point I only have bg colors in place for each area. Once the basic layout is there, then I'll pretty it up a bit and add in some default content.
Etc, etc.
For me it's much faster to go through it once and do it right, then to have to go back and reformat a bunch of code spit out by a program. But to each their own, as long as the tables are kept to tabular data.