Well.... When everything is working at top speed...
802.11n = 300Mps (usually 220Mps - 2500Mps in real-world use)
USB2 = 480Mps (Can be as low as 100Mps if your other USB ports are busy)
... Most people would go USB I think but the best option really depends on your computer.
I'm not sure if I read if you have a laptop or desktop. If your main Mac is a MacBook/Pro then you don't really want to use up one of your 2 USB ports for backups. Add to that you wouldn't really want a external HD handing off your computer all the time as you move it around. Not when putting the backup disk on the network only drops your backup time by 1 or 2 minutes.
If you have a iMac or Mac Pro when I'd use USB for the extra speed because you aren't moving the computer around and you have more ports the spare on these machines. Or even better.... does the Hard Drive have a Firewire 800 option?? using that could get you up to 800Mps.
Until ThunderBolt drives come along!
ThunderBolt 10,000Mps
Your connection to external drives is the same as your connection to your built-in drive at that point. Cables don't matter then. 🙂