I don't think they are. What kind of 15" do you have. If it's a TiBook, then they are not compatible at all. The 12" uses DDR while the 15" TiBook uses SDRAM. If you have a 15" AlBook, then they are sorta compatible, as they are both DDR, but the 15" PB's RAM runs at a higher speed than the 12". I think it's okay to use different speed memory, although it's not recommended. I think all the RAM will slow to the speed of the slowest one.