Best thing to do is try and handle it patiently. Packing up and moving can be good or bad, all depends on how, why, etc.
Sounds cliché, but making a pros and cons list usually works well for me, particularly with many pack up and moves I've done. 🙂 And I'd definitely involve your wife throughout the entire process.
Do some research about the locations you are thinking of moving to as well. Locale is just as or more important than the job, IMO.