YouTube and iTunes? By iTunes you mean the music player, or the WiFi store? What exactly won't work?
What do you mean that YouTube doesn't work? Videos that were uploaded before sometime in 2007 (I think) aren't encoded correctly for the Touch, and they won't work. If *some* videos work on YouTube, but not all of them, then that's probably what you're experiencing. If the YouTube app itself isn't working, then I think we'd need more details.