yeah I just tried it in wow, doesn't work. It works in other games though. But then again I don't play WoW in full screen if even at all lol I just have it. If you can, play in windowed mode if you need to tab into different programs
The multitouch is recognized in teh background but you can't see the cmd+tab bar. the mouse arrow turns into a finger though but can't click out. so yeah..