No, you'll probably experience a tad more compatibility, and less laggy/slow flash player
I'd actually recommend this if you plan on watching flash content while on battery. The Flash player is more bloated on OS X than Windows as it is, and by using a wrapper to use the still 32-bit plugin in 64-bit Safari is known to tax many CPUs (just search around here, people's laptops getting hot and fans spinning up when playing flash content). All because Adobe can't get a 64-bit version out the door.