iAntivirus does not scan for threats to Windows. So, if you wish to run AV software to avoid being a hub for windows malware, then iAntivirus is useless.
Also, most of the malware definitions in iAntivirus are for legacy Mac OS (not Mac OS X) or the malware are legitimate software that has to be installed locally with authentication by entering the admin password. So, unless someone that was aware of the admin password installed a legitimate keylogger (not malware, used for legitimate purposes but can be abused) on your system, iAntivirus does not protect from as much malware as it advertises.
The relevant malware definitions in iAntivirus are for trojans that can easily be avoided with user knowledge. Also, definitions for most of these trojans (3 of 4 at this point in time) are included in XProtect that is built into Snow Leopard.
I would suggest using ClamXav if you wish to run AV software on your Mac to prevent forwarding Windows malware via email. ClamAV (same engine as ClamXav) is primarily used on email servers (default AV in Mac OS X server) so its definitions are biased toward threats that are distributed via email. ClamXav's set of definitions for Mac OS X include all relevant threats to Mac.
Do not use the quarantine feature if you set ClamXav to scan emails. The Sentry feature of ClamXav can be used to set up rudimentary real-time scanning for specific folders. A benefit of ClamXav is that it does not require elevated privileges (root) to be effective. Not running as root is important for the security of client side software that receives user defined input (ClamXav = definition updates).
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