Wirelessly posted (Mozilla/5.0 (iPhone; U; CPU iPhone OS 4_3 like Mac OS X; en-us) AppleWebKit/534.32 (KHTML, like Gecko) Version/5.0.2 Mobile/8F190 Safari/6533.18.5)
It will be computer free. Meaning iCloud will backup, deliver all past purchases, etc I don't see the actual sync method changing from this beta. I expect you still have to make one tethered connection in order to say "this is the iTunes I want to sync with". Otherwise how will they manage it? If you set it up from the phone what's to keep me from just go to a random persons house and syncing all their data? Or if it is managed from the computer what is to keep me from polluting your phone with crap? Unless they add some convoluted passcode system, I see the initial wired hook up being required of you want to sync with a computer.
Re-read my post - I think it will be tied to Apple/iCloud ID. It makes sense to utilise local backup, both from Apple and the user point of view. My way seems like the most secure and simple.
Not sure if my post didnt quote it right (on my phone so I'm not going to go back and find it) but I was replying to a user saying this wireless sync will help the fact that 50% of iPhones brought into the apple store have never been synced, therefore they have no backup. I meant to imply that the wireless sync will not help with that due to still having to set it up at first. ICloud will help making sure users have backups available. Not sure if it will really help since I foresee most users that are not capable of syncing their phone, being capable of setting up iCloud. Maybe apple stores will do it for them?
I'm not sure if you've used iOS 5, but there is a setup screen when the device is first turned on that goes through the activation of iCloud. It would appear likely that a larger proportion of users will have iCloud activated.