I got a buddy with one of the original (yes original iPhones). He wants to update to iTunes 10 and then iTunes 11 in a few days. Will the latest iTunes still support his original iPhone?
It will work (for the most part iTunes will be backwards compatible for previous hardware). I've had 2G, 3G, 4 and 5 plugged into my computer within the last month and a half and all run fine on a late 2011 MBP w/ all updates current.