My only concern is the cuda thing. I need to use it for AE and I don't want to cripple the app because i'm inpatient.
The CUDA drivers depends on a matching video card driver as its counterpart. If you update your system to 10.8.3 then the video driver has a higher version number than the CUDA driver — thus making CUDA at least unstable, but more likely completely disables all CUDA functionality. OpenCL might still work.
So, if you depend on CUDA for your work, best advise is to stay with 10.8.2 and the 10.8.2 WebDriver from NVidia for a few days longer. Based on the pattern of earlier Mac OS X releases, I think it is safe to assume that NVidia will release an updated CUDA Driver in a few days from now.
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Update: Here's a semi-official statement in the NVidia forum concerning CUDA drivers for 10.8.3.
https://forums.geforce.com/default/topic/534924/geforce-drivers/cuda-update-for-mac-os-x-10-8-3/
Looks like we don't have to wait very long.