I can't speak of the app store version. However, the fall patch for the steam version, as well as the recent mini-patch that has been rolled into the app store update, made significant improvements to general performance, graphics performance and gameplay. It also fixed various UI bugs and has been very well received by players using both PCs and Macs.
Patch notes
I see no reason why the campaign edition wouldn't benefit from all the improvements that were made to the steam version, especially considering the extra time that Aspyr have had to test it. One thing to mention, though. I understand that the initial update posted to the app store was bugged, causing problems at startup, but that it was fixed very quickly. No one seems to be complaining of any issues on the Civfanatics Mac forums.
TL;DR: A very worthwhile update. Do it!