At first, was using a Griffin eSATA ExpressCard/34 (
http://www.griffintechnology.com/products/esataexpresscard), but learned that its Silicon Image chipset is problematic with Mac 10.5+ OS. Learned that eSATA cards w/ JMicron JMB360 chipset are natively supported by the Mac OS. I bought a PCMC-EXP34-1S2 (
http://www.computercablesource.com/pcmcia-expresscard-1x-esata-port-34mm-jmicron-chipset-1686.html) from Computer Cable Source (
http://www.computercablesource.com/). Unfortunately, it looks like the two-port eSATA card they sell is based on the Silicon Image chipset. Perhaps a two-port JMicron-based card is available elsewhere.
I see that Sonnet Tech (
http://www.sonnettech.com/product/tempo_sata_express34.html)has a warning message on their website for their Tempo SATA ExpressCard/34: "Temporarily not recommended for Mac systems with greater than 2GB of memory." Looks like Iomega's eSATA 3Gbps 2-port ExpressCard/34 (
http://www.iogear.com/product/GPS702e3W6/?PHPSESSID=fb059044e229a4d70806379d8660bb10) only supports 10.4 of the Mac OS (on the View All tab, under Requirements). This is consistent with Silicon Image chipsets that don't play well with 10.5+. Griffin tech support confirmed the same challenges.
Griffin Technology recommended, and I agree, that in System Preferences for your Mac, under Energy Saver, UN-check putting the hard disk(s) to sleep when possible.
Hope this helps. Keep us posted on your progress.
(The third party Mac OS drivers for the Silicon Image chipset are old and have not been updated in several years, hence the compatibility issues. Learned all this through troubleshooting and googling.)