Steps to take to streamline and maximize resources/efficiency in Lion?

My Mac is running just fine on 10.7.3, but with my Windows 7 machine I am always trying to find new ways to streamline it for my purposes and maximize my resources (hard drive space/memory/etc). It's not that I have to do it, it's that I enjoy doing it. I still have quite a bit to learn about OS X, so I am wondering if there any helpful tips, guides, etc regarding this.

Thanks.

Thanks everyone. I have to go view an apartment very soon but I will continue going through this advice and seeing what I can do that I haven't done yet.

So far:

Page Outs - 125kb
Clicktoflash - Check
Widgets - Killed that with terminal already. I don't use this feature and I didn't really like the way it looked.
No log in items checked
No startup items found in /Library/StartupItems/
Flash is up to date
HTML 5 video player is now enabled. I found this particularly cool, was not aware that Google was even doing this with Youtube.
AdBlock installed since day 1.
DNS settings are normal.

I'm pretty familiar with Activity Monitor, so I check that every now and then just to make sure everything is running optimally.

I'm about half way through removing unneeded fonts, most of them just being ones in foreign languages that I will not need. Any other tips are welcome.