The external iSights are Firewire 400. Those came out during the time of Aluminum PowerBook G4s and iBook G4s. If there is a Firewire 800 iSight, I've not seen it.
Ram is important, but in the case of Skype or VOIP it's less important than CPU. What happens is when processing gets intense (as it does with USB cams) the CPU spikes. The longer the CPU pegs at 100% the hotter the processor gets (of course). So, you get a busy processor which causes Skype to drop video frames during the call. Eventually you get a frozen picture on your screen. Then the fans kick in to lower the CPU temp. Invariably, the person you are talking to will hear the fans. It comes over as static.
So, unless you have a good USB cam that does not peg the processor I'd stick with a Firewire iSight.
You can test your USB cam. Plug it in and make sure it's ready to go before you open Skype. Go to Preferences in Skype and select the video tab. Activate the camera. Watch your CPU. If it goes into the 70 to 90% range you can be pretty sure it's not going to work well in the actuall call.
There are two well known apps that will show your CPU in the menubar if you do not already have them. MenuMeters and iStat. I used to use MenuMeters, but iStat is superior in the information it presents.