I also have two 4 bay FW800 Drobos. They are connected to a Mac mini and I regularly access the Drobos from my Mac Pro via File Sharing. Write speeds I've seen are usually around 16-20MB/s. Read speeds are around 23-24MB/s. These figures are for large files (think 1GB+). Figures will probably be lower when moving lots of small files. Not great but, for my needs, acceptable. Write speeds drop when the Drobos are getting full. Every single one of the drives in both Drobos have been upgraded since purchasing them and I've never lost any data on them. The larger the drive you are upgrading to, the longer the rebuilding process takes. If I recall correctly, upgrading a 1.5TB drive to a 2TB drive took close to 2 days for the rebuild to complete.
I don't have any personal experience with any of the other models that Drobo offers but, from what I've read, the newer models include faster CPUs and more memory which should help performance.
I also have an 8 drive unRAID NAS array. I've seen write speeds of approx 30MB/s and read speeds of around 64-70MB/s (again, these figures are when moving large files). I recently upgraded one of its 1TB drives to a 2TB drive and it took approx 18 hours to finish the rebuild.
When I purchased my Drobos, I was unaware of other products that allowed for the mixing and matching of drives with the ability to dynamically upgrade any of the drives. Plus, at about $320, the Drobos seemed reasonably priced for the peace of mind that the redundancy would offer me. Overall, I've been very happy with them.
When I found out about unRAID and realized that it offered the same abilities to mix and match drives and dynamically upgrade any of the drives like the Drobos, I was intrigued. Since it involves building and configuring the NAS yourself, it can be as cheap or as expensive as you decide to make it. I started off with a 4 bay Intel SS4200 NAS that I got for $135 and later added an external 4 bay eSATA enclosure for $110 to upgrade the array from 4 drives to 8 drives. So, my 8 drive array actually cost less than either of my Drobos! But, again, it involves rolling up your sleeves and getting your hands a little dirty to get it all up and running.
When upgrading drives, it involves clicking a few buttons on the web-based GUI whereas nothing needs to be done on the Drobos other than swapping out the drives. Also, currently, AFP is not built-in and needs to be added-on manually by the users. Lime-Technology is working on having AFP built-in and I'm expecting a beta any day now.