Without knowing the exact structure of the spreadsheet its difficult to tell for sure but excel is pretty powerful. Try something along the lines of:
1. Export the file to a commonly used type, I recommend CSV.
2. If you have Excel, hopefully you also have Outlook and can import the files (look on the net, there are quite a few guides)
3. Sync iPad to Outlook.
If you are on a mac try using Address Book instead of Outlook for the import.