I've been user trim-enabler on multiple fusion setups, though my current one doesn't need it (spare SSD from rMBP). I've always enabled it after installation or time-machine restore.
I'm not sure how TRIM works with a fusion setup - does it even matter? My understanding is the coreStorage migrates large blocks between the drivers based on usage, so it may be large enough trim doesn't matter, or it may be there's basically never any unused space.
However I figure any garbage-collection on the drive won't understand any fusion setup, and since I'm also encrypting I have to assume it can't do any garbage collection -- so maybe TRIM will help, but it certainly won't hurt...
I wouldn't expect the command-line hacking to be any different than using TrimEnabler - you'll probably have to redo every OS update, but it should be sticky.