I have a Loka (the regular one, not the UL) also -- it's amazing.
However, the large ICU won't take a 15" laptop. Well, it's true that I managed to jam my rMBP into the sleeve, but after I thought about it for a while I realized that was too dangerous. True, I could have put it in a sleeve and gotten it in, but I was carrying another small bag anyway (ThinkTank Urban Disguise 60) so I put the rMBP in that. If I'd had no choice, I'd have found a way, as Crank47 did.
Here's what I packed in mine, the last time I traveled with it - for 3 weeks, in car and plane:
D810
70-200
14-24
105 micro
Marantz PD661 field recorder with AC charger
Sony RX100 2 plus its own charger and extra batteries
D810 charger and 2 batteries
Garmin GPS
CF card reader
two 2.5" enclosures, with cables
small shotgun mike and some XLR cables
and a bunch of little stuff
The Loka is a great, great unit.
Also, I liked dealing with them directly. Unlike the majority of vendors I deal with online, they didn't rip me off on shipping to Hawai'i.