For nostalgic reasons, I can strongly recommend Civ IV as a mouse centred game.....you need the keyboard if you want to enter a new name (as opposed to default) at the start
Just downloaded the 'complete' set from Steam....and played it from start to finish without a single hiccup on OS X.
Just switched from a windows PC, so this was a very pleasant surprise.
There are some posts in relation to Civ V having some issues under ML so I'm steering clear until that's fixed.