Thank you for the information above, but yes. What applications / utilities / system hacks / whatever are running? What OS version?
Try to run Activity Monitor (or top from the command line) and sort by % CPU. See what your highest items are... When you are not doing too much actively, you should usually see just a few items with <25% or so of CPU including the focused app and maybe a couple of system items. If anything shows up as taking >75% of CPU, then there might just be a task that has gone wild for some reason. You can often kill the task and it will just restart. Depends on what it is. It could be associated with a bad preferences file, which won't be solved by anything on your to-do list. But if you know what program it is, you can spotlight for the preference file and delete it. 🙂
Also, if that does not turn out to be the case, and this is a Tiger thing... try for a moment, shutting down Safari and seeing if other programs become snappier when Safari isn't running. I have had this weird issue recently where Safari occasionally causes the whole system to gum up. I have not been able to figure it out. Sometimes, the Reset Safari menu item solves it temporarily. Other times, I end up getting frustrated and using Firefox for a while....