Female here - 5'5" with pretty small hands...and I LOVE LOVE LOVE my iPhone 6+. I was actually hesitant after the first review came out (back when the shells were released) where a guy had said the 6+ was obnoxious to use and just "too big" but then when the cut outs popped up here on MacRumors, I printed them out and found the 6+ size seemed perfectly fine to me. I also tried out my friend's Note 3...so after all of that, I made the decision to go with the 6+.
I'm also a hobbyist photographer, so the OIS was very appealing, as was the larger screen to view/take photos, and the 1080p screen....bigger battery just sweetened the deal. That being said, even if specs were identical, I would have opted for the 6+ for the bigger screen.
I am not worried about carrying it in pants pockets, because it always goes in the front pocket of my purse, and the 6+ fits inside my purse pocket perfectly while in the Apple silicone case.
I have always been a two-thumbed texter, so no change there, and I can still text and operate the phone with one hand, but it is a stretch and I have to adjust the phone in my hand (which makes it a little unstable), to try and reach the opposite side, but not a deal-breaker to me at all.
It is perfect...FOR ME...and I haven't had any hesitations since I opened the box on Friday. I adore it, and fall more and more in love with it the more I use it.
As others mentioned, definitely try taking a trip to the store to check them out in person...and if you can't get to a store, check out the cut outs that someone posted here on MR. I liked them (as opposed to some of the others) because you can actually fold them into a 3D format so that you can get an idea of the thickness AND the size. If you want me to link you to the post, just let me know.