Temujin is correct, they will act as one single monitor. The Dual Head 2 Go product appears as a single monitor, double width. So if you are using two 1280x1024 screens, your Mac will think you have one 2560x1024 screen. You will be able to place this single 'screen' however you want in relation to the internal screen (using the digital model at full 2x1920x1200 resolution requires the laptop be used in lid-closed mode, though,) but you cannot change the two external screen's location with respect to each other. You have to place them side-by-side with 'monitor 1' on the left, and 'monitor 2' on the right. (Numbers based on the ports on the Matrox box.) They can be physically different monitors, such as yours, but they must both support the same resolution. (If the CRT only supports 1024x768, you can use the 2x1024x768 resolution on the Matrox box, which will present to your computers as a single 2048x768 monitor.)