I think so. I learned (i.e., self-taught) on a PC with photoshop 6 (or 7, can't remember now) and when I finally got to use photoshop on a mac it was much better. Mostly just because I didn't have to obsessively save save save for fear of the system crashing and losing my stuff. Now I get angry about having to reboot once every couple of months because I have to save tons of things I have open in photoshop. 😛
Then again, I'm bias and think almost everything is better on a mac.