The volume could be up too high, and your speakers might be distorting.
Or, I don't know if your mac uses a digital amp or not - but if it does...
My 24" white imac, does that too -- in my case, sadly it's my digital amp. Startup chime sounds scratchy / grainy - and once in the OS, the speakers make a continuous whine that changes pitch each time a sound is made. I don't like it. But I forgot to return it during warranty. 🙁