I tried Civilization IV (both base and Warlords version) -- both require the CD be in the superdrive and that part of it works OK.
However, when you turn on one of the game options (show grid lines to easily identify the game squares) the program crashes with a "Divide by zero" exception in the graphics driver. If I don't turn on the option the game plays OK. That doesn't have anything to do with your problem, but I thought I'd mention it anyway 🙂