1) defragment the main harddrive?
2) make a backup of the entire harddrive or certain folders? Would like to burn the backup.
3) optimize?
4) Any other procedure you guys take on a monthly basis?
1. Usually don't need to on a Mac.
2. Not sure, I'm terrible at backups 🙁
3 and 4. Periodically repair permissions in Disk Utility. Also, periodically run "sudo periodic daily weekly monthly" in the Terminal.
HFS+ (at least in 10.3, maybe in earlier versions of Mac OS) is kind of self-defragmenting. Whenever a file is opened a set of conditions are checked which are something like is the file fragmented and less than 20Mb and not a heap file. If these conditions are true then the file is moved to a new location on the disk that will result in it being defragmented. So you don't need to defrag.