I have a couple of AMD quads and I know they would not be able to handle bigadv units, though it is possible the new chips might work ok. AMD don't have 2 threads per core, so the OS thinks there are only 4 cores instead of the 8 with Intel chips. My phenom II x4 965 did really well with regular units under Linux but now that I have 3 gpu's on it with windows - not so much...