Just an FYI for anyone who is considering upgrading OS X at the moment. I'm running a MacPro5,1 and had a GTX 680 for Mac installed. Cloned system drive to a backup and then updated to OS X 10.8.5. All is running fine with the machine after the update. As expected, the NVIDIA Driver manager is not compatible with the OS X version and defaults back to the OS X default driver through the manager preferences. Would expect/hope to see an updated driver posted in 2-3 weeks. If I can easily tell which version of the drivers Apple is using in 10.8.5, please let me know and I'll report that information. Adobe software has had no issues with this update at the moment.