Are you running Lion? After upgrading to Lion it no longer works for me.
You don't need a scanner driver. Just open "Image Capture" with the multifunctional hooked to the computer and there you go...
Samsung SCX-4100 works with Mac OS X 10.10.4!
Using the advice from jf8 and MacTiger14 i just got my fathers old Samsung printer/scanner working with OS X 10.10.4.
I got the printer working by downloading and installing the printer driver from Samsung for SCX-4500. OS X "sees" the SCX-4100 printer but you have to assign the printer driver for SCX-4500 to it. This is done in system settings/printers.
I also downloaded the scanner driver and software for SCX-4500 but only installed the driver. I am not confident with using the terminal and to edit the above mentioned files required root privileges. The easy solution is to copy the files, make the changes, save, erase the original files and replace them with the edited files (admin privileges needed). Filenames have to be identical.
Pay attention to that App Store software update will suggest to install a newer Samsung printer driver but that will break scanning. You have to make the changes in the files again to make it work.
I'm swedish so excuse my somewhat strange "accent".
With Vuescan you should be able to use the scanner.Any tricks for El Capitan?! It seems that the solution doesn't work on Mac OS X El Capitan... Thanks.