I'm trying to get serious about backing up my family's iMac and the strategy I'm working with now is this: The 750 GB internal HD is cloned every week, using SuperDuper, to a 750 GB external HD attached via FireWire to the iMac. I have (on order) a 2 TB external HD attached via USB to my AEBS (located in my basement and attached to the iMac via ethernet) that I will use as a Time Machine backup for my iTunes library (I have iTunes Match so this may be unnecessary) my iPhoto library, my home movies and my documents. This way I have coverage from accidentally deleting a file (Time Machine) and coverage if my internal HD fails and I need to get back up and running quickly (Cloned HD). I'deventuallylike to have a second cloned 750 GB drive so that I can alternate and keep one offsite (will SuperDuper alternate between the two?). Am I missing anything? I'm running Mountain Lion if that makes any difference.