My iMac G4 LCD/800 runs this unit at about 36 minutes per frame. Of course, even among proteins of the same unit variations are seen in run/clone/gen numbers. Also, is this a dedicated folding machine or do you use it for other processor intensive tasks? This will affect frame times as well. The unit you are running is a Tinker unit. Tinkers are not so hot when running on G3 and G4 processors. They take an eternity because no Cobalt compiler is available to enhance the Tinker core code for Macs. Yes, Tinkers are bad on PCs, but Macs are much worse. My iMac estimates completion at 10 days, so your G4/500 will take even longer to complete the unit. Keep on folding on!