I used my wife's new Nokia Lumia 900 which has a 4.3" screen exclusively for a weekend doing all kinds of routine tasks that I would do on my iPhone, and now I am convinced that 3.5" screen is the ideal if you want to consistently use a phone one handed without straining to reach things on the screen. Anything beyond 3.5" (or at most 3.7") just doesn't work for one handed use at least for me and I have normal sized hands. Confession: I am the guy who started this thread http://forums.macrumors.com/showthread.php?t=1355401 and thought Apple was arrogant to push another 3.5" sized iPhone on us. Frankly I was just enamored with the large screen Android phones that I played with a few times at the AT&T store which look great when you use it only for a few minutes. But for prolonged use the smaller iPhone is much more comfortable, I have to admit. Seems like Apple knows what it is doing after all. Having said that if you are somebody that uses their phone two handed, definitely the bigger screenmay work for you. Still a lot of people say that they can fit their huge 4.5", 4,7", 5" phones easily in the pocket because they are so thin so they don't see an issue with the size. But IMHO I think the phone size is most important when you are trying to use it and not whether you can slip it easily in and out of pockets.