I don't see how. I am literaly doing my best to move the cursor with any part of my palm both on my Retina MBP and on my Magic Trackpad 2 with no success. It's almost a bit scary - with the finger it reacts to the lightest touch, but with my palm, or side of the palm - it doesn't matter if I touch lightly, with a small part of skin, or hard - with full rest on the trackpad - I cannot move the pointer at all.
It's one of those things where some people say they are having trouble, but I just can't reproduce it.
I'm convinced it won't be an issue for me.