I'm going absolutely nuts here. No matter what I do, I cannot eliminate the pops and crackles when the polyphony rises to only 5 on some of my virtual instruments (using Sytrus). For a little background, this is what I'm using: Intel Pentium 4/3.0GHz 2GB DDR533 RAM 80GB SATA HD M-Audio 2496 Audiophile XP Home w/SP2 ASIO4All drivers FL Studio XXL There is NOTHING else on this system; I only use it for music. I have been unable to get rid of the audio pops forever. I've tried just about everything, both with the M-Audio driver and ASIO drivers. I've tried every latency setting, interpolation, etc. and nothing seems to help. Do Macs have this issue? If not, that's all I need to know to make a switch. I never had this issue back when I used Cakewalk 8 and Acid Pro 4 with a Sound Blaster Live Platinum. I've read a ton of forums to look for tips, but they all say the same thing. I don't get it. This computer is more than powerful enough to do what I need it to do. I see people which much less doing much more.