I've been unable to find a satisfactory answer to this question searching the net... I love Airtunes with iTunes + iPhone remote app. It's easy, works well, and the wife understands it. However, being that it uses wireless, I have problems with audio dropout and disconnections on occasion that is very frustrating. I'm looking to rewire the house with dedicated speakers and a multimedia closet that will stream the music to different rooms, but I want to be able to still use the remote app on the iPhone so I can turn on and off rooms as I do now with the remote app. My thoughts initally involve an Mac Mini with a couple of USB-sound-cards attached and each one feeds a room. However, I can find no information on whether iTunes understands multiple sound cards and can send them the audio feed like it sends the Airports. I can also not seem to find any information as to whether OS X can easily handle multiple sound cards. Does anyone know if this can be done, and/or describe or link to a solution that would allow the use of a mac/iTunes + remote (or other similar iPhone app) to control multiple room sound?