Thinking about thinking about...
My $.02 = If you're thinking about an SSD for a new iMac, Thunderbolt is the way to go, IMHO. Depending on which adapter/which SSD you choose, you can get the maximum throughput available on the drive without opening the case, or paying the rather high Apple SSD tax. There's lots of testing on the forum to bear this out.
Cheapest/most compatible route is the Seagate Backup Plus Desktop adapter (STA129; $150) and a single SSD of your choice, plus the Apple Thunderbolt cable ($49.00).
Faster than USB 3.0
More stable than USB 3.0, especially under heavy CPU load
Trim supported
Compatible with Boot Camp/Windows.
Another variation:
Pegasus J4 Thunderbolt Enclosure ($387.00) and up to four SSDs of your choice, plus the Apple Thunderbolt cable ($49.00).
Faster than USB 3.0
More stable than USB 3.0, especially under heavy CPU load
Trim supported
NOT Compatible with Boot Camp/Windows at this time; Pegasus tech support sez it's a new product, a Windows driver will be forthcoming but no ETA on it.
I'm going to be using both. I've tested both setups with TBolt on a late 2011 MacBook Pro, and they work crazy fast, both enclosures sleep and wake just fine, etc.