I am running a 2010 Mac mini with High Sierra on it on an Seagate Barracuda 500GB drive. If I do a cold reboot, it goes through the boot process pretty quickly and successfully. However on warm reboots it does not and ends up giving me the gray circle with a gray backwards slash icon. I know that large capacity HDD have had problems but this is only 500GB. This unit had a 250GB Crucial SSD in it with absolutely no problems for a number of years. Any suggestions other than replace the SSD?