Being a right-hand dominant dude, I hold the phone with that hand. My right pinky is always used to support the iPhone on the bottom, which I believe is quite common... I am sure most everyone holding their phone right now instinctively just ran this test and will agree. When I have my earpods plugged in, it's forcing me to almost latch onto the earpods connector that feeds into the dock while texting. This may cause some early retirement for pods/connector issues over time. Just something non-ergonomically correct, in my opinion. My wife, on the other hand (see what I did there?), is left-handed. She hasn't used my 5 yet, so no idea how the southpaws are going to be affected. Still, digging my new 5.