I used to use Freeway and RapidWeaver. Personally, I much prefer RapidWeaver - although you're stuck with their themes to a certain extent (although, with a little technical skill, you can create your own).
More recently I've gone over to using WordPress* for pretty much everything and personally I don't see me going back. Of course, it's not a desktop app but it's very effective and there are heaps of themes and plugins to choose from. I'd suggest you at least give it a go.
Good luck!
Rob
* No, I don't work for them!