prefer...
I use Photoshop (there is no equal), illustrator, Golive, Flash.
I used to use Quark, then got into InDesign. Now can't go back to Quark. Quark is dying. I loved it for a long time but I just cant stand for the (old) constant updates (3.31, 3.32, 4.0, then back to 3.32) with no real feature changes and the lack of the update to OSX (yes, I know it's in the works). I don't hate Quark, and I see no need to take sides, because for a very good long time Quark was king. Slowly the torch is being passed. Adobe does an amazing job of intergration. Sure, InDesign 1.0 has some MAJOR flaws, the fixed most of them in 2.0. Now it's a good layout program.
I was taught in my design classes that it's not what programs you use to get the job done, but rather that the final product that comes from the job grabs attention and provokes thought.