well for external drives i kno it can support the Bigger Disk by Lacie which is 1 Terabyte......so i would guess that it will support the drives you want, but they are internal so i would look around apple's support pages to be sure
Since you will be adding a card to control them, yes, they will work. Serial ATA (SATA) cards are seen by the BIOS as SCSI cards (just like Parallel ATA (IDE/EIDE) (both simple and RAID) cards) and all disk management is handed off to the cards.