Using a Wii remote with Nestopia ROCKS! My only reason was to play games not yet available on the Wii (c'mon Nintendo). Seemed very stable and quite functional.
It was quite simple to partner the remote with my MBP, a quick visit to the Preferences allowed me to map keys and save it as a profile. Fire up Nestopia and all I could say is WOW!
In any case, I never figured out if you can use two Wiimotes...Anyone had any luck with this?