Bluetooth Keyboard with RF mouse?

Would it be possible to mix a bluetooth keyboard with an RF mouse? I do not have internal bluetooth so I'm going to have to get the D-link adapter. I'm guessing that the RF products also use an adapter plugged into a USB port so I'll probably be wasting 2 USB ports, correct?

Besides that issue would there be an interference or other issues?

I like Apple's BT keyboard but the one button mouse is kiling me.
I just can't find a BT mouse that I like. I don't want to connect a Microsoft mouse to my iMac and Logitech's MX900 is hard to find and I just don't like the look of it.