Since OSX doesn't support crossfire or SLI, I have a weird question. If I had two video cards in my machine, and were using an application that takes advantage of OpenCL or CUDA, which of the two cards would do the heavy lifting?
Most applications will let you choose which one.
Other apications will just use the GPU you have your screen attached too and some applications, like in my case Octane Render, can use all GPUs in the Mac Pro.
So you need to tell us what applications your using. But you could just use google and tje tech support from the developers of the application
The only applications I am concerned about is final cut pro X motion 5 and compressor 4.