You must be new to this whole "Apple Computer" thing.
If you mean using them since 1995, then yes, im new.
Are you sure? Looking at OWC's mid-2010 Quad-core RAM page here: http://eshop.macsales.com/shop/memory/Mac-Pro-Memory#1333-memory the identical sticks note only applies to using 8GB sticks.
Here's what Crucial says about the mid-2010 Quad-core:
"...you can install modules one at a time, and you can mix different densities of modules in your computer. But if your computer supports dual-channel memory configurations [this model doesn't—NCAM], you should install in identical pairs (preferably in kits) for optimal performance."
Hmm, Apple's online specs are mute on the subject, so I downloaded the User Manual. Here's what it says:
"Note: If you install different-size DIMMs in your Mac Pro, follow the order in the table. If the DIMM configuration you install doesn’t provide optimized performance, the Memory Slot Utility appears onscreen and recommends an improved configuration.
To use the utility again, go to /System/Library/CoreServices/Memory Slot Utility."
So I think that establishes that mix-and-match is allowed, although they should be installed in a certain order. It would certainly simplify things to use all the same though, but since Apple ships weird base configurations—3 x 1GB in a 4-slot Mac, what's that all about?—it's hard to do that without excessive wastage.
Too bad that Apple is stuck in the Bad Old Days on MacPro RAM pricing. A $1775 adder to go from 3GB to 16GB? Yeah, like that's going to happen.
See: https://forums.macrumors.com/threads/995581/
All the information you need should be in there