if the machine's out of warranty/applecare warranty (this voids any warranty), you can flash the drive's firmware. it's now pretty safe, and just resets the drive to RPC1 instead of RPC2 - meaning you need still to set the region when watching DVDs, but instead of five resets you can reset it as many times as you like, using a program such as Region X.
that'd be the best bet, it's the most convenient.