With a three-channel DDR3 memory controller, Nehalem requires the use of three DDR3 modules to achieve peak bandwidth - which also means that the memory manufacturers are going to be selling special 3-channel DDR3 kits made specifically for Nehalem. Motherboard makers will be doing one of two things to implement Nehalem's three-channel memory interface on boards; you'll either see boards with four DIMM slots or six.
In the four-slot configuration the first three slots correspond to the first three channels, the fourth slot is simply sharing one of the memory channels. The downside to this approach is that your memory bandwidth drops to single-channel performance as you start filling up your memory. For example, if you have 4 x 1GB sticks, the first 3GB of memory will be interleaved between the three memory channels and you'll get 25.6GB/s of bandwidth to data stored in the first 3GB. The final 1GB however won't be interleaved and you'll only get 8.5GB/s of bandwidth to it. Despite the unbalanced nature of memory bandwidth in this case, your aggregate bandwidth is still greater in this configuration than a dual-channel setup.