I have the Dell 24 inch 4k attached to my 5k iMac. I can tell you there is a difference. The 5k iMac is that much sharper.
When I first got the Dell 24 I connected it to my rMBP 13 inch which could only drive the display at 30hz, so I returned that and waited until they got it right.
Don't get me wrong, the Dell 24 4k monitor is great on it's own. If you could drive that 60hz, it's great. The way OSX does spaces and multi tasking, and also allows individual spaces PER DISPLAY is truly amazing. I'll have a video playing full screen on the 4k, with xcode and such on my 5k display. I can swipe with 4 fingers on the 4k monitor between that, limechat, maybe safari. etc while maintaining the xcode on my 5k display. All with no lag on the base model. Only lag is the mission control animation, which I think another thread confirmed per Apple Support Engineer that they're aware of the issue and a fix is coming.
Another thing that amazes me is that it's super aware. if I turn off the display, all the applications come back to main 5k screen, I turn on the display and all the applications immediately go back into their former position on the 4k screen.
I usually don't mix resolutions, but for what I use the 4k monitor for, IRC / light reading or videos, plus OSX does such a great job with it's retina implementation, it makes it a joy to use.