You can leave the original 8GB in for a total of 72.I asked this very question of a rep at Other World Computing. If I understood, while there may be a very slight increase in performance in four 16 GB modules, if one might ever want to increase to 128, then the two 32 GB modules would be preferable so that one would not have to chuck all the memory and buy four 32 GB modules. I plan to purchase two 32's after my BTO comes in.
It is possible that OWC is referring to a comparison test that was on gaming. Tested one band and one RAM module configuration (single rank). I found the result interesting but likely not universal.Intel's desktop CPUs have a Dual-Channel memory interface. I have no idea what that OWC rep was smoking but clearly he/she had no idea. There is absolutely no difference at all between two and four modules.